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Anti-glycation

OBJECTIVE: PROTECTING THE SKIN FROM GLYCATION FOR MAINTAINING ELASTICITY AND SKIN TONE UNIFORMITY

Glycation is also known as the Maillard reaction. It is a reaction between proteins and sugar (carbohydrates) which leads to irreversible binding of proteins to each other.

GLYCATION AND SKIN

Glycation is a reaction that will have an impact on the skin. Proteins of the dermis (mostly the collagen fibers) will react with free sugars (mainly glucose) which will lead to their reticulation (crosslinking), i.e. their irreversible bonding of the fibers to each other.

In the dermis, collagen fibers form a network which interactions and movement with one another provide good elasticity and flexibility to the skin. Crosslinking will therefore greatly reduce the fibers’ motricity and thus the skin elasticity and flexibility.

Glycated fibers are also going to get colored which will participate in the loss of a uniform complexion.

The more the fibers are glycated, the more they are colored

Finally, the glycated proteins will be metabolized into AGEs (advanced glycation endproducts) which are both pro-glycants and mutagenic agents. They will affect skin cell survival.

CONSUMER’S EXPECTATIONS

  • Protecting the skin from glycation
  • Preserving the skin flexibility and elasticity
  • Preserving skin tone uniformity
  • Protecting skin cell integrity 

EXSYMOL’S ANSWER

In order to combat glycation, Exsymol has developed a 3-step strategy.

Step 1 – Prevention: Preventing the sugar from reacting with collagen fibers

Scavenging free sugars within the dermis

Scavenging free sugars before they react with collagen fibers protects the skin preventively from the effects of glycation.

Alistin

Silysin

Arct’Alg

Limiting the attachment of sugars to collagen fibers

Silicium has a high affinity for collagen fibers. By interacting with them, it will limit the sites of sugar fixation on the fibers.
This will thus reduce glycation in a preventive way.

Algisium

Silysin

Step 2 – Repair: Dissociating sugar from the collagen fibers

Transglycation makes it possible to repair the already glycated fibers

In the case of glycation, the bond between sugar and a protein is irreversible. Exsymol has developed an active ingredient capable of transglycation. It is capable of substituting itself to the collagen fiber and thus to release it, to repair it.

Alistin

Step 3 – Palliation: Protecting the skin from the effects of AGEs

Glycated proteins are degraded and generate AGEs (advanced glycation end-products) which will cause a de novo glycation, and which can degrade the surrounding cells’ DNA due to their highly mutagenic nature.

Limiting the effect of AGEs, even after the glycated protein has been degraded.

Limiting the impact of AGE prevents de novo glycation. This ensures good flexibility and good elasticity to the skin, but also good uniformity of the complexion.

Since AGEs are also extremely mutagenic, DNA is protected from dermal cells to ensure their survival and proper functioning.

Alistin

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