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Cell communication


The skin is a complex organ composed of several compartments (epidermis, DEJ, dermis and hypodermis), each composed of several types of cells.

Each cell communicates with the surrounding cells and influences their activity. They can stimulate or inhibit them.

Over time, or because of some stress, the metabolic activity of skin cells slows down. Their ability to support surrounding cell activity decreases which will have a strong impact on the overall health of the skin.

By ensuring good cell communication, the activity of all skin cells is normalized


  • A firmer and denser skin
  • Skin tone unniformity
  • Hydration / barrier function
  • Slenderness


To meet these expectations, Exsymol has developed active ingredients that improve communication between the different skin cells.

Keratinocytes – fibroblasts interactions

Keratinocytes stimulate fibroblast proliferation

The keratinocytes from the epidermis secrete cytokines that stimulate the proliferation of fibroblasts fromthe dermis.

Over time, or because of stress, the support capacity of keratinocytes decreases and the rate of proliferation of fibroblasts slows down. Their number will decrease and this will have an impact on skin density.

By ensuring good communication between keratinocytes and fibroblasts, a good density is ensured to the skin.


Fibroblasts – adipocytes interactions

Fibroblasts stimulate adipocytes’ lipolytic activity

Dermal fibroblasts secrete NO (nitric oxide) which stimulates the lipolytic activity of adipocytes.


Fibroblasts – melanocytes interactions

Fibroblasts stimulate melanocyte activity

Dermal fibroblasts secrete KGF (keratinocyte growth factor) which role is to stimulate the proliferation of keratinocytes, and which can also stimulate the production of melanin by melanocytes. The transport of KGF to the epidermis is regulated by perlecan, a proteoglycan of the DEJ.

When the DEJ is damaged, this control is no longer assured and the melanogenesis is over activated which leads to the appearance of stains.

By ensuring the integrity of the DEJ, the activity of the melanocytes is standardized to ensure a uniform complexion.


Nerve cells interact with all skin cells

Nerve cells – keratinocytes interactions for barrier function

In the epidermis, nerve cells promote the proliferation and differentiation of keratinocytes. They thus ensure a good barrier function.


Nerve cells – adipocytes interactions

In the hypodermis, nerve cells produce norepinephrine which stimulates the lipolytic activity of the adipocytes.


Nerve cells – keratinocytes/fibroblasts/adipocytes interactions

The keratinocytes from the epidermis, the fibroblasts from the dermis and the adipocytes of the hypodermis all produce NGF (nerve growth factor) which will ensure the survival and differentiation of the nerve cells in each of the compartments of the skin.




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