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Epidermis

OBJECTIVE: IMPROVING SKIN PROTECTION AND HYDRATION AND ENSURING SKIN TONE UNIFORMITY

The epidermis is the most superficial layer of the skin. Its main role is to protect the body against external aggressions while ensuring a good hydration to the skin via its barrier function.

The epidermis is a stratified epithelium composed 4 to 5 layers depending on the level of keratinocyte differentiation, and there are several types of cells with distinct properties:

  • Keratinocytes form a real protective wall that protects the skin from external aggressions and preserves the skin’s moisture through the barrier function.
  • Melanocytes are the cells that synthesize melanin which role is to absorb UV and thus to protect the skin against solar radiation. Melanin is a dark pigment, it will also modulate the complexion (phototype, homogeneity …)

The epidermis as a target of choice

Over time, or because of some stress, the epidermis becomes thinner, the skin becomes dry and more and more vulnerable.

By specifically targetting the epidermis, we will be able to address several cosmetic claims:

CONSUMERS’ EXPECTATIONS

  • Hydration / barrier function
  • Protection
  • Regeneration
  • Wound healing
  • Skin tone uniformity

EXSYMOL’S ANSWER

To meet these expectations, Exsymol has developed actives that specifically target the epidermis, and more precisely some cells that compose it.

Specific action on keratinocytes

Hydration / barrier function: Strengthening the cohesion between keratinocytes

Some proteins are markers of hydration in the epidermis.

  • Filaggrin ensures good cohesion between keratinocytes to limit water loss
  • Aquaporin ensures the intracellular hydration of keratinocytes

Epidermosil

Arct’Alg

Protection: Strengthening the skin defensive capacities

Pollution, UV radiation and some stress affect the integrity of the epidermis.

Redivine

Epidermosil

Arct’Alg

OTZ-10

Alistin

Regeneration : Stimulating keratinocyte proliferation

By increasing the number of keratinocytes, the thickness of the epidermis is increased. The most superficial wrinkles are filled, the skin is better hydrated and better protected.

Algisium

Epidermosil

Glistin

Wound healing : Ensuring keratinocyte proliferatio and migration

After an injury, keratinocytes must recolonize the space. But with age or because of stress, their migratory capacity decreases which affects the entire wound healing process.

Epidermosil

Glistin

Targetting stem cells or transiant amplifying (TA) cells

Some actives target specific populations of keratinocytes such as stem cells or progenitor cells (transiant amplifying cells).

Epidermosil

Glistin

Resynchronizing keratinocytes and biorythmchrono

Age, fatigue, jet lag, etc. can desynchronize keratinocyte metabolisms which can have an effect on the epidermis quality.

Chronocyclin

Specific action on melanocytes

Normalizing melanocyte activity for regulating skin complexion

The main role of melanocytes is to produce melanin. When their activity is disturbed, it affects the skin tone homogeneity, especially by causing age spots.

Ascorbosilane

Sirhamnose

Entadine

Albatin

Stimulating melanocyte activity for sublimating the tan

Melanocytes produce melanin from tyrosine aminoacid. By providing tyrosine to melanocytes, their ability to synthesize melanin is facilitated.

This leads to a natural tan improvement.

Tyrosilane

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