IMPROVING THE SKIN FIRMNESS AND OBTAINING A SLENDER SILHOUETTE
The hypodermis is the deepest skin compartment. It contains adipocytes, the cells responsible for absorbing fat from the blood stream. They also store fat as triglycerides in lipid droplets.
The thickness of the hypodermis varies according to location and gender.
The mass of adipose tissue is regulated by three complementary mechanisms:
- Adipogenesis – synthesis of adipose tissue
- Lipogenesis – fat absorption and storage
- Lipolysis – fat excretion
The hypodermis as a target of choice
Over time, because of a stress, or because of hormonal changes (menopause), adipocyte activity will be altered. This can lead to the appearance of unsightly curves.
By specifically targeting the hypodermis, we will address several cosmetic claims:
- Control of the stored fat volume
To meet these expectations, Exsymol has developed active ingredients that specifically target the hypodermis, and specifically the adipocytes.
Specific action on adipocytes
Increasing lipolysis for promoting fat elimination
By stimulating lipolysis it promotes the elimination of fat and refines the silhouette.
Inhibiting lipogenesis for limiting fat absorption
By limiting the ability of fat cells to absorb fat, it is possible to avoid getting back fat, especially after a diet.
Inhibiting adipogenesis for limiting fat storage capacities
By inhibiting adipogenesis, the number of mature adipocytes capable of storing fat is reduced. This makes it possible to avoid getting back fat, especially after a diet.
Action on the other cells of the hypodermis
Protecting nerve cells for reducing the effects of stress
Nerve cells produce norepinephrine that stimulates the lipolytic activity of adipocytes. In return, the adipocytes produce NGF that ensures the survival of nerve cells.
Cortisol (the stress hormone) inhibits the production of NGF by adipocytes which will affect the survival of nerve cells in the hypodermis. These nerve cells will no longer be able to stimulate the lipolytic activity of the adipocytes.
By ensuring the survival of the nerve cells within the hypodermis, it provides good support for adipocytes for regulating the fat content.
Normalizing fibroblast activity for preventing cellulite
Adipocytes are gathered into lobules which shape depends on gender (spherical for men, diamond-shaped for women). These lobules are maintained by type IV collagen fibers. In case of an inflammation, the collagen fibers multiply and thicken until completely isolating the lobule which becomes painful and is responsible for the effect of orange peel.
By normalizing fibroblast activity, the collagen overproduction is avoided together with this fibrotic effect at the origin of cellulite.