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Dermal-epidermal junction

OBJECTIVES :

IMPROVING THE SKIN RESISTANCE AND ENSURING A GOOD UNIFORMITY TO THE SKIN

The dermal-epidermal junction (DEJ) is a structure at the interface between the epidermis and the dermis. It measures about 80nm and assures several role within the skin:

  • It ensures a good cohesion between the epidermis and the dermis for a strong resistance against a possible physical stress
  • It ensures the good communication between the cells from the dermis and those from the epidermis
  • It serves as a matrix for the migration of keratinocytes in case of an injury
  • It ensures keratinocyte orientation for their differentiation and proliferation
  • It regulates melanin synthesis by melanocytes

The dermal-epidermal junction as a target of choice

Over time, or because of some stress, the dermal-epidermal junction becomes thinner and can even break in places. This leads to a loss of physical resistance and the appearance of age spots.

CONSUMERS’ EXPECTATIONS

  • Even skin tone
  • Firm and tonic skin

EXSYMOL’S ANSWER

To meet these expectations, Exsymol has developed actives that specifically target the dermal-epidermal junction.

Targetting the DEJ for an even skin tone

The DEJ regulates melanogenesis

Dermal fibroblasts secrete KGF (keratinocyte growth factor) which main role is to stimulate keratinocyte proliferation. KGF can also stimulate melanin production by melanocytes. The transport of KGF to the epidermis is regulated by perlecan, a proteoglycan of the JDE.

When the DEJ is damaged, this control is no longer assured and the melanogenesis is overactivated which leads to the appearance of age spots.

By ensuring the integrity of the DEJ, melanocyte activity is normalized and the skin tone uniformity is ensured.

Sirhamnose

Targetting the DEJ for ensuring the skin biomechanical properties

The DEJ as a guarantee of skin resistance

The DEJ ensures the good cohesion between the epidermis and the dermis. Its thinning, or rupture, causes a decrease in the physical resistance of the skin.

A healthy DEJ ensures a good physical resistance to the skin.

Algisium

Sirhamnose

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