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Combating the effects of psychological stress


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The weather, the environment, our lifestyle, and our own metabolisms are all potential sources of premature aging of the skin, with visible consequences such as dehydration, loss of elasticity, age spots, etc.

Having analyzed skin changes exposed to different stresses, we have found that this breakdown in skin quality is due to a deterioration in its structures and organization, reduced cellular communication and cooperation, with subsequent slowing in cutaneous metabolisms.

Cellular communication takes place at all levels of the skin, in the epidermis, dermis and hypodermis. There are exchanges between different cells in the same compartment, or between cells in different compartments. This cellular communication enables cells to assist and support each other. It is thus essential to maintain these changes at all levels.

Weather and our lifestyle (food, stress, etc.) also have an impact on our capacity to store fats. With age, we also tend to accumulate more fat.

The aim is thus to offer an active ingredient capable of preserving cellular communication from aging effects and foster the elimination of fats.

EXSYMOL’s answer

How it works

The skin is a complex organ made up of different types of cells, including nerve cells. They play a key role in the various cellular metabolisms because they secrete cytokines capable of stimulating the action of other skin cells. In return, the other skin cells (keratinocytes, fibroblasts and adipocytes) secrete NGF (Nerve Growth Factor) which ensures the survival and development of nerve cells.

With aging, all skin cell metabolisms slow down. In the hypodermis, adipocytes produce less NGF, which affects nerve cells and they can in turn no longer support adipocyte activity.

GLUTRAPEPTIDE offers an original approach to cellular communication. By protecting nerve cells in the hypodermis, it supports adipocyte activity with their capacity to eliminate fats.

General properties

GLUTRAPEPTIDE (INCI name: PYROGLUTAMYLAMIDOETHYL INDOLE) is an “optimized peptide” capable of fostering the survival and development of nerve cells in the hypodermis via an NGF-like effect.

This active ingredient has been specially designed to reach the hypodermis and have an effect on adipocyte activity.

Cosmetic benefits

Consumer benefits

  • Slimming
  • Firming
  • Reduces the accumulation of fat due to psychological stress

Skin benefits

  • Preventing neurodegeneration
  • Stimulating fibroblast contraction
  • Inhibiting the effect of cortisol on lipolysis

Customer benefits – Original concepts:

  • Neuroprotection
  • Neuroslimming
  • Complementary action to caffeine

The expert’s opinion

GLUTRAPEPTIDE is a neuroprotector

GLUTRAPEPTIDE is capable of substituting NGF and thereby fostering the survival of nerve cells in the hypodermis.

GLUTRAPEPTIDE combats the effects of cortisol on lipolysis

During periods of chronic psychological stress, cortisol (the stress hormone) is produced and has an impact on cells in the hypodermis:

  1. It inhibits NGF production through adipocytes which leads to neurodegeneration
  2. As a result of neurodegeneration, neurons secrete less norepinephrine which reduces lipolysis (capacity of adipocytes to eliminate fats)
  3. Cortisol stimulates adipogenesis (differentiation of preadipocytes into mature and functional adipocytes)

Through the cortisol effect, psychological stress is thus responsible for the increasing number of adipocytes which have a very low fat excretion capacity.

GLUTRAPEPTIDE is capable of substituting NGF and thereby fostering the survival of nerve cells in the hypodermis to increase their capacity to excrete fats for a slimming effect.

GLUTRAPEPTIDE is a slimming aid that is complementary to caffeine with a synergetic action

GLUTRAPEPTIDE’s action is focused on cellular communication between adipocytes in the hypodermis and nerve cells. It is thus entirely compatible with traditional lipolytical treatments such as caffeine, for a synergetic effect.

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