Redivine

Anti-pollution (environmental and domestic)

Volatile pollutants + household dust + artificial rays
(blue light: domestic and multimedia)

Combats oxidative stress

Anti-aging

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YOUR EXPECTATION

Pollution is one the consequences of our modern societies and although more and more people and governments are ready to reduce their emissions, the general public is still highly exposed to pollutants.

We are not only exposed to outside pollution (cigarette smoke, exhaust gases, ozone, the sun’s rays, etc.), but also interior pollution (household dust is often rich in heavy metals, artificial light, etc.).

Accumulating domestic pollutants

Progress has enabled our homes to be better insulated for more comfort and better energy control.

This is also a trap which leads to a concentration of pollutants in our living spaces (homes and offices).

Because air is not renewed very often, we often find a higher concentration of pollutants inside than outside.

Urban pollution, a threat to cells

• Microparticles from urban pollution (20 times smaller than skin pores),
• Domestic carbon monoxide (heating, cigarette smoke),
• Domestic pollutants (furniture glue, paint solvents, etc.),
• Light radiation: blue light emitted by artificial light and multimedia, infra-red from our heat sources.

A multitude of pollutants penetrate the skin, generating free radicals that reach skin cells and structures.

Pollution thus indirectly produces cutaneous disruption with visible repercussions:

• Skin sensitivity: redness, dryness, irritation
• Skin dryness
• Dull complexion
• Age spots
• Skin breakdown
• Premature aging

Limiting the accumulation of pollution damage and thereby preventing premature aging is therefore essential.

This aim is all the more important when pollution is combined with other extrinsic factors such as sunlight (Ultra Violet A & B, Infra-Red, etc.), lifestyle (smoking, nutrition, psychological stress, etc.) which are also responsible for provoking premature aging.

EXSYMOL’S ANSWER

How it works

Through cellular mechanisms, skin can defend itself and protect itself from damage that might be caused by various sources of pollution.

Among these natural defense mechanisms, the combination of “xenobiotic response elements” (XREs) and “anti-oxidant response elements” (ARE) is especially effective against urban pollution.

The XRE can degrade pollutant particles.  However, this degradation generates ROSs, the presence of which triggers AREs, responsible for producing several antioxidants.

REDIVINE offers dual action, providing at the same time direct protection by trapping ROSs, and indirect protection by reinforcing cutaneous cell defenses (XRE and ARE).

General properties

REDIVINE (INCI name: Vitis vinifera (grape) leaf extract) comes from the ORGANIC farming of red grape vines in the Castile area – La Mancha, Spain, which is one of the most important vineyards in the world since the late 19th century. REDIVINE is a COSMOS approved active ingredientrich in anti-oxidant polyphenols (flavonoids).

COSMETIC BENEFITS

Consumer benefits

Skin benefits

Our added value:

EXPERT’S OPINION

Natural protection mechanism against volatile pollutants

The ARE is orchestrated by a specific transcription factor: Nrf2.

Nrf2 is a free radical detection sensor.

During oxidative stress, it fosters neosynthesis of antioxidants such as glutathione and Nqo1 to rebalance skin homeostasis as quickly as possible.

Domestic pollution

Although urban pollution is relatively well described and understood, interior pollution is still not understood.

In fact, we are often exposed to solvents (paint, glue, make-up, etc.), to carbon monoxide, particles, etc.

In addition, we tend to close windows to protect us from pollution outside, and in this way pollutants such as heavy metals (lead, etc.) accumulate in household dust. Exposure to household dust is responsible for damage caused to the skin.

Moreover, inside, we are constantly exposed to artificial light from bulbs and/or computers. Overexposure to these various types of artificial light can also affect skin and provoke premature aging.

XRE (Xenobiotic response element), a defense mechanism against pollutants.

In cytoplasm, BaP is bound by the transcription factor AhR (1) which moves into the nucleus and sticks to the DNA (2) to stimulate production of a detoxifying agent, CYP1A1 (3). This protein traps BaP (4) and metabolizes it (5). Unfortunately, this detoxification process is accompanied by the forming of certain metabolites which generate free radicals (6).

ARE (Antioxidant response element), a defense mechanism against oxidative stress.

Nrf2 is a transcription factor that can measure the quantity of free radicals in a cell. In oxidative stress, Nrf2 is stabilized and translocated in the nucleus where it stimulates the synthesis of antioxidants like NQO-1 or glutathione. These antioxidants then reduce oxidative stress and facilitate a return to cellular homeostasis.